Nanoplastics Influence Alpha-Synuclein: Insights into Parkinson’s Disease

Insights into Parkinson's Disease

A study led by Duke University reveals a correlation between nanoplastics, derived from polystyrene, and alterations in brain proteins linked to Parkinson’s disease. The research, conducted in solutions, cultured cells, and genetically modified mice, indicates an abnormal accumulation of alpha-synuclein proteins in the presence of nanoplastics. Notably, strong chemical bonds form between polystyrene nanoparticles and alpha-synuclein in cell lysosomes, hindering natural neuronal waste disposal. While these early findings lack human trials, they underscore the potential impact of nanoplastics on protein levels. Future research, utilizing advanced monitoring technologies, is imperative to understand the health implications of ubiquitous microscopic plastic particles.

Source: https://www.science.org/doi/10.1126/sciadv.adi8716

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