A novel method has been developed by the University of California San Diego researchers using synthetic biology to slow down the deterioration of cells as they age. After studying the gene circuits that control the aging process in cells, they genetically rewired the circuit to operate as a clock-like device called a gene oscillator. The oscillator drives the cell to periodically switch between two detrimental “aged” states, avoiding prolonged commitment to either and slowing the cell’s degeneration. The rewired circuit resulted in an 82% increase in lifespan for yeast cells, setting a new record for life extension through genetic and chemical interventions.
