Keratosis extremitatum, also known as Greither’s disease, is a rare genetic skin disorder characterized by the development of thick, warty growths on the hands and feet. These growths typically appear during childhood or adolescence and gradually increase in size and number over time.
The exact cause of Keratosis extremitatum is not fully understood, but it is believed to be inherited in an autosomal dominant pattern, meaning that a mutation in a single gene passed down from one parent can lead to the development of the condition.
Symptoms of Keratosis extremitatum may include thickened, rough, and hyperkeratotic (excessively keratinized) skin on the palms of the hands and soles of the feet. The growths may be yellowish-brown in color and can cause discomfort or pain, particularly when they become large or interfere with normal activities.
Treatment for Keratosis extremitatum typically focuses on managing symptoms and may include regular trimming of the thickened skin, moisturizing creams or ointments to soften the growths, and in some cases, surgical removal of the lesions. However, treatment options may vary depending on the severity of the condition and individual patient needs.